Which symptom is most characteristic of Sjogren's syndrome?

• A. Dry eyes
• B. Dry skin
• C. Weight gain
• D. Abdominal pain

Answer: (A)

Sjogren's syndrome is an autoimmune condition that mainly targets moisture-producing glands, especially the lacrimal and salivary glands. This leads to dryness of the eyes and mouth, with the eye dryness being the most characteristic feature. Reduced tear production causes irritation, a gritty or burning sensation, red eyes, and discomfort with reading or exposure to wind. While dry mouth is also common, the ocular dryness is the hallmark finding. Dry skin, while it can occur in various conditions, and symptoms like weight gain or abdominal pain are not typical features of Sjogren's.