Klinefelter syndrome is associated with which condition?

• A. Infertility
• B. Cardiac abnormalities
• C. Renal abnormalities
• D. Cancer

Answer: (A)

Klinefelter syndrome involves an extra X chromosome in males (47,XXY), which leads to testicular dysfunction and hypogonadism. This impaired testicular function causes reduced or absent sperm production, so infertility is by far the most characteristic feature. The other options aren’t defining associations of this condition in standard exam contexts; cardiac or renal abnormalities aren’t the hallmark, and while individuals may have other health considerations, infertility specifically reflects the gonadal impact of the XXY pattern.