In recurrent aphthous ulcers, which medication can be prescribed?

• A. Cimetidine
• B. Prednisone
• C. Omeprazole
• D. Sucralfate

Answer: (A)

Managing recurrent aphthous ulcers often requires more than topical measures when lesions are frequent or disabling. Cimetidine, an H2 receptor blocker, has historically been used for this condition because it can modulate immune responses in the oral mucosa. This immunomodulatory effect may help reduce ulcer frequency and promote healing in some patients, and it is generally well tolerated and easy to take as an oral medication.

Prednisone can rapidly suppress inflammation, but its systemic side effects limit use to short courses for severe disease. Omeprazole targets acid production and doesn’t address the mucosal immune processes involved in RAU. Sucralfate provides a protective coating over ulcers but is typically used topically; it doesn’t offer the same systemic potential for reducing recurrence. Therefore, among these options, cimetidine stands out as a reasonable systemic option to prescribe for recurrent aphthous ulcers.