In fibrocystic breast disease, which medication should be avoided because it contains estrogen and can worsen symptoms?

• A. Oral contraceptive pills
• B. Leuprolide
• C. Naproxen
• D. Danazol

Answer: (A)

Fibrocystic breast changes are influenced by hormones, especially estrogen, which can stimulate breast tissue and worsen cyclical pain and cyst formation. Therefore, therapies that contain estrogen can aggravate symptoms. Oral contraceptive pills include estrogen, so they are avoided in managing this condition. Other options listed work differently: leuprolide lowers estrogen levels, naproxen helps with pain, and danazol has anti-estrogenic effects. When contraception is needed in this context, progestin-only or nonhormonal methods are often preferred.